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Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity.

Original publication




Journal article



Publication Date





570 - 574


Action Potentials, Animals, Cell Membrane, Clathrin-Coated Vesicles, Dynamin I, Dynamin II, Dynamin III, Electric Stimulation, Endocytosis, Excitatory Postsynaptic Potentials, Exocytosis, Inhibitory Postsynaptic Potentials, Mice, Mice, Knockout, Microscopy, Electron, Neurons, Patch-Clamp Techniques, Presynaptic Terminals, Synapses, Synaptic Transmission, Synaptic Vesicles