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Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the function of ANXA1 in the brain and have proposed several possible mechanisms by which it exerts a neuroprotective or anti-neuroinflammatory function. We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions.

Original publication

DOI

10.1016/j.tips.2007.12.003

Type

Journal article

Journal

Trends Pharmacol Sci

Publication Date

03/2008

Volume

29

Pages

135 - 142

Keywords

Animals, Annexin A1, Anti-Inflammatory Agents, Brain, Humans, Nervous System Diseases, Receptors, Formyl Peptide