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This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.

Original publication

DOI

10.1007/s00424-011-0964-z

Type

Journal article

Journal

Pflugers Arch

Publication Date

07/2011

Volume

462

Pages

39 - 48

Keywords

Animals, Models, Cardiovascular, Myocardial Contraction, Myocytes, Cardiac, Stress, Mechanical