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Two types of exogenous K channel were identified in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting cell line HIT T15. One of these was the ATP-regulated K channel (G channel) as evidenced by its conductance and inhibition by tolbutamide. The other resembled the Ca-activated K channel from beta-cells.


Journal article


Febs lett

Publication Date





185 - 189


Animals, Calcium, Cell Line, Cell Membrane, Female, Insulin, Islets of Langerhans, Membrane Potentials, Oocytes, Poly A, Potassium Channels, Protein Biosynthesis, RNA, Messenger, Tolbutamide, Xenopus laevis