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Cardiac electrophysiology is affected by cardiac mechanics. The input from the heart's mechanical environment to its electrical behaviour has been termed mechano-electric feedback (MEF) and is well documented by more than a century of clinical observations on mechanical modulation of heart rate and rhythm. The mechanisms underlying cardiac MEF have been investigated for only a few decades and include stretch activation of ion channels and mechanical modulation of cellular Ca2+ handling. This review briefly outlines the scope and limitations of current experimental insight and its implementation in mathematical models of cardiac cellular activity.

Original publication

DOI

10.1098/rsta.2001.0824

Type

Journal article

Journal

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Publication Date

15/06/2001

Volume

359

Pages

1173 - 1185