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In 1970 the Boulder Committee described the basic principles of the development of the CNS, derived from observations on the human embryonic cerebrum. Since then, numerous studies have significantly advanced our knowledge of the timing, sequence and complexity of developmental events, and revealed important inter-species differences. We review current data on the development of the human cerebral cortex and update the classical model of how the structure that makes us human is formed.

Original publication




Journal article


Nat Rev Neurosci

Publication Date





110 - 122


Animals, Body Patterning, Cell Differentiation, Cell Lineage, Cell Movement, Cerebral Cortex, Humans, Neural Pathways, Neuroglia, Neurons, Stem Cells