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Cardiac fibroblasts form one of the largest cell populations, in terms of cell numbers, in the heart. They contribute to structural, biochemical, mechanical and electrical properties of the myocardium. Nonetheless, they are often disregarded by in vivo and in vitro studies into cardiac function. This review summarizes our understanding of fibroblast origin and identity, their structural organization and role in myocardial architecture, as well as functional aspects related to cell signalling and electro-mechanical function in the heart.

Original publication

DOI

10.1016/j.cardiores.2004.08.020

Type

Journal article

Journal

Cardiovasc Res

Publication Date

01/01/2005

Volume

65

Pages

40 - 51

Keywords

Animals, Electrophysiology, Fibroblasts, Gap Junctions, Humans, Myocardial Contraction, Myocardium, Signal Transduction