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The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.

Original publication




Journal article


Exp Physiol

Publication Date





307 - 321


Animals, Arrhythmias, Cardiac, Electrophysiology, Heart, Heart Conduction System, Humans, Ion Channels, Mechanoreceptors, Mechanotransduction, Cellular, Membrane Potentials, Models, Cardiovascular, Physical Stimulation, Research, Research Design, Ventricular Function