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Ion channels and G-protein-coupled receptors (GPCRs) play a fundamental role in cancer progression by influencing Ca(2+) influx and signaling pathways in transformed cells. Transformed cells thrive in a hostile environment that is characterized by extracellular acidosis that promotes the pathological phenotype. The pathway(s) by which extracellular protons achieve this remain unclear. Here, a role for proton-sensing ion channels and GPCRs as mediators of the effects of extracellular protons in cancer cells is discussed.

Original publication

DOI

10.1152/physiol.00005.2011

Type

Journal article

Journal

Physiology (Bethesda)

Publication Date

08/2011

Volume

26

Pages

252 - 265

Keywords

Animals, Calcium, Calcium Signaling, Disease Progression, Humans, Hydrogen, Ion Channels, Neoplasms, Protons, Receptors, G-Protein-Coupled