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Post-mortem studies by Galaburda and colleagues on the brains of developmental dyslexics found characteristic neuronal abnormalities: ectopias, microgyria, and fewer large-soma cells in sensory thalamus. An association between dyslexia and immune dysfunction has also been proposed. We describe a mechanism which may explain these observations. Platelet-activating factor (PAF) is a pro-inflammatory lipid implicated in neurological disorders. We propose that PAF may also be involved in dyslexia.

Original publication

DOI

10.1054/plef.2001.0258

Type

Journal article

Journal

Prostaglandins Leukot Essent Fatty Acids

Publication Date

03/2001

Volume

64

Pages

173 - 180

Keywords

Brain, Dyslexia, Genetic Linkage, Humans, Platelet Activating Factor