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The Physiome Project, exemplified by the Cardiac Physiome, is now 10 years old. In this article, we review past progress and future challenges in developing a quantitative framework for understanding human physiology that incorporates both genetic inheritance and environmental influence. Despite the enormity of the challenge, which is certainly greater than that facing the pioneers of the human genome project 20 years ago, there is reason for optimism that real and accelerating progress is being made.

Original publication

DOI

10.1113/expphysiol.2008.044099

Type

Journal article

Journal

Exp Physiol

Publication Date

05/2009

Volume

94

Pages

597 - 605

Keywords

Biological Evolution, Biophysical Phenomena, Computational Biology, Electrophysiological Phenomena, Heart, Humans, Mathematical Concepts, Models, Cardiovascular, Models, Genetic, Systems Biology