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A tetrodotoxin-sensitive persistent sodium current, I(pNa), was found in guinea pig ventricular myocytes by whole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium, midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant (P<0.05) smaller I(pNa) than subendocardial and subepicardial myocytes. There was no significant difference in I(pNa) current density between subepicardial and subendocardial cells. Computer modeling studies support a role of this current in the dispersion of action potential duration across the ventricular wall.


Journal article


Circ Res

Publication Date





910 - 914


Action Potentials, Animals, Cadmium, Calcium Channels, Computer Simulation, Guinea Pigs, Heart Ventricles, In Vitro Techniques, Lithium Chloride, Models, Cardiovascular, Myocardium, Organ Specificity, Patch-Clamp Techniques, Sodium, Sodium Channels, Sodium-Calcium Exchanger, Tetrodotoxin