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In pathological conditions, the exchanger may generate deleterious calcium entry. A drug that inhibited calcium entry, while still allowing transport of calcium out of the cell would then seem attractive. In fact, this is impossible for thermodynamic reasons. Inhibitors may appear to be more effective when the exchanger is operating in net calcium entry mode than in calcium exit mode. This is, however, always attributable to differences in conditions because there is strong internal sodium dependence of drug action on the exchanger. When the exchanger is operating near equilibrium, drug action is found to be equally effective in both directions.

Original publication

DOI

10.1196/annals.1387.013

Type

Journal article

Journal

Ann N Y Acad Sci

Publication Date

03/2007

Volume

1099

Pages

540 - 543

Keywords

Sodium-Calcium Exchanger, Thermodynamics