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The cyclic adenosine 3',5'-monophosphate signalling pathway is now recognised to transduce signals in a compartmentalised manner such that individual stimuli only engage a subset of the pathway components that are physically constrained within defined subcellular locales, thus resulting in a precise functional outcome. As we are starting to appreciate the complexity of the spatial organisation and of the temporal regulation of this pathway, it is becoming clear that disruption of local signalling may lead to pathology and that local manipulation of cAMP signals may offer alternative approaches to treat disease.

Original publication




Journal article


Curr Opin Pharmacol

Publication Date





649 - 655


Animals, Biological Transport, Cyclic AMP, Heart Diseases, Humans, Molecular Targeted Therapy, Myocytes, Cardiac, Phosphodiesterase Inhibitors, Second Messenger Systems