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Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

Original publication




Journal article


Brain Res

Publication Date





93 - 97


Action Potentials, Animals, Denervation, Dopamine, Electron Transport Complex IV, Energy Metabolism, Male, Mesencephalon, Neurons, Oxidopamine, Parkinsonian Disorders, Raphe Nuclei, Rats, Rats, Sprague-Dawley, Serotonin, Sympatholytics, Synaptic Transmission, Up-Regulation