Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

The purpose of this study was to look at the connectivity of the posterior inferior hypothalamus in a patient implanted with a deep brain stimulating electrode using probabilistic tractography in conjunction with postoperative MRI scans. In a patient with chronic cluster headache we implanted a deep brain stimulating electrode into the ipsilateral postero-medial hypothalamus to successfully control his pain. To explore the connectivity, we used the surgical target from the postoperative MRI scan as a seed for probabilistic tractography, which was then linked to diffusion weighted imaging data acquired in a group of healthy control subjects. We found highly consistent connections with the reticular nucleus and cerebellum. In some subjects, connections were also seen with the parietal cortices, and the inferior medial frontal gyrus. Our results illustrate important anatomical connections that may explain the functional changes associated with cluster headaches and elucidate possible mechanisms responsible for triggering attacks.

Original publication

DOI

10.1016/j.jocn.2006.07.012

Type

Journal article

Journal

J Clin Neurosci

Publication Date

10/2007

Volume

14

Pages

955 - 960

Keywords

Autonomic Nervous System, Biological Clocks, Brain Mapping, Brain Stem, Cerebellum, Cerebral Cortex, Cluster Headache, Deep Brain Stimulation, Diffusion Magnetic Resonance Imaging, Efferent Pathways, Electrodes, Implanted, Humans, Hypothalamic Diseases, Hypothalamus, Posterior, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Male, Middle Aged, Models, Statistical, Nerve Net, Reticular Formation, Sensitivity and Specificity, Tomography, X-Ray Computed