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Cancer metabolism produces large fluxes of lactate and H+, which are extruded by membrane transporters. However, H+ production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.

Original publication

DOI

10.1016/j.cmet.2024.02.003

Type

Journal article

Journal

Cell Metab

Publication Date

05/03/2024

Volume

36

Pages

461 - 462

Keywords

Carnosine, T-Lymphocytes, Lactic Acid, Membrane Transport Proteins