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Understanding how the human cerebral cortex evolved to its present complex state is a fascinating topic for neuroscience, genetics, bioinformatics and comparative biology. To gain further insights into the origins of the mammalian neocortex and to understand how the cortex evolved to be able to serve more complex cognitive functions, we study the development of various extant species. Our aim is to correlate cortical cell numbers and neuronal cell types with the elaboration of cortical progenitor populations and their modes of proliferation in different species. There are several progenitors, i.e. the ventricular radial glia, the subventricular intermediate progenitors and subventricular (outer) radial glia types, but the contribution of each to cortical layers and cell types through specific lineages is not fully understood. Recent comparisons of the proportions of these progenitors in various species during embryonic neurogenesis have revealed the elaboration and cytoarchitectonic compartmentalization of the germinal zone, with alterations in the proportions of various types that can be included among the intermediate progenitors. Across species, larger and more diverse intermediate progenitor populations correlate with brain size and cortical cell diversity. Understanding the molecular and cellular interactions regulating the divisions of these intermediate progenitors not only has implications for cortical evolution but also relates to stem cell biology and illuminates the pathomechanisms of several cortical developmental disorders.

Original publication




Journal article


Brain Behav Evol

Publication Date





94 - 107


Animals, Biological Evolution, Brain Mapping, Cell Differentiation, Cell Proliferation, Cerebral Cortex, Humans, Neuroglia, Neurons, Stem Cells