Plasmonic ELISA for the detection of gp120 at ultralow concentrations with the naked eye.
Cecchin D., de la Rica R., Bain RES., Finnis MW., Stevens MM., Battaglia G.
The technique of plasmonic ELISA is utilised here to detect the HIV-1 protein gp120 with the ultralow limit of detection of 8 × 10(-20) M (10(-17) g mL(-1)) in an independent laboratory. It was corroborated that changes in the concentration of hydrogen peroxide as small as 0.05 μM could lead to nanoparticle solutions of completely different tonality.