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Secretory phospholipase A2 group IIA (sPLA2-IIA) was examined as a point of care marker for determining disease activity in rheumatoid (RA) and psoriatic (PsA) arthritis. Serum concentration and activity of sPLA2-IIA were measured using in-house antibodies and a novel point of care lateral flow device assay in patients diagnosed with varying severities of RA (n = 30) and PsA (n = 25) and found to correlate strongly with C-reactive protein (CRP). Levels of all markers were elevated in patients with active RA over those with inactive RA as well as both active and inactive PsA, indicating that sPLA2-IIA can be used as an analogue to CRP for RA diagnosis at point of care.

Original publication




Journal article



Publication Date





4482 - 4485


Adult, Aged, Arthritis, Psoriatic, Arthritis, Rheumatoid, Biomarkers, C-Reactive Protein, Enzyme-Linked Immunosorbent Assay, Female, Group II Phospholipases A2, Humans, Male, Middle Aged, Point-of-Care Testing