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Iodide-mediated surface etching can tailor the surface plasmon resonance of gold nanostars through etching of the high-energy facets of the nanoparticle protrusions in a rapid and sensitive way. By exploring the underlying mechanisms of this etching and the key parameters influencing it (such as iodide, oxygen, pH, and temperature), we show its potential in a sensitive biosensing system. Horseradish peroxidase-catalyzed oxidation of iodide enables control of the etching of gold nanostars to spherical gold nanoparticles, where the resulting spectral shift in the surface plasmon resonance yields a distinct color change of the solution. We further develop this enzyme-modulated surface etching of gold nanostars into a versatile platform for plasmonic immunoassays, where a high sensitivity is possible by signal amplification via magnetic beads and click chemistry.

Original publication




Journal article


Angew Chem Int Ed Engl

Publication Date





9891 - 9896


gold nanostars, horseradish peroxidase, iodide, plasmonic immunoassay, surface etching, Biocatalysis, Biosensing Techniques, Gold, Horseradish Peroxidase, Iodides, Metal Nanoparticles, Oxidation-Reduction, Surface Properties