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Age-related white matter hyperintensities are associated with cognitive impairment and dementia. Venous insufficiency has recently been proposed as a potential mechanism for the development of periventricular white matter hyperintensities based on the neuroanatomic distribution. The current study assesses age related changes of the internal jugular veins and its association with white matter hyperintensities. A retrospective study was performed assessing patients with computed tomography angiography (CTA) and magnetic resonance imaging (MRI) within a 4-week window. The size of the internal jugular veins, straight sinus, vein of Galen and internal cerebral veins were measured on the CT angiography. A normalized neck venous ratio was developed. Burden of white matter hyperintensities were quantified on MRI using periventricular/deep Fazekas scores. Association was assessed using correlation analysis and multrivariate linear modeling, and differences between groups were assessed using t test, ANOVA or Kruskal-Wallis test, using p 

Original publication

DOI

10.1002/ca.23926

Type

Journal article

Journal

Clin Anat

Publication Date

10/2022

Volume

35

Pages

974 - 978

Keywords

anatomy, imaging, neuroanatomy, Aged, Aged, 80 and over, Cerebral Veins, Female, Humans, Jugular Veins, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, White Matter