Review of historic article: Skou 1964 enzymatic aspects of active linked transport of Na+ and K+ through the cell membrane. Progress in Biophysics and Molecular Biology, 14, 133-166.
In this historic article we witness the author's own account of his great discovery: the nature and location of the enzyme system enabling sodium-potassium exchange across membranes in living cells, particularly nerve cells. That discovery has stood the test of time. active ion transport of sodium and potassium ions through cell membranes is ubiquitous.