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The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

Original publication

DOI

10.1038/nrn2995

Type

Journal article

Journal

Nat Rev Neurosci

Publication Date

03/2011

Volume

12

Pages

169 - 182

Keywords

Animals, Biological Transport, Blood-Brain Barrier, Brain, Cerebrovascular Circulation, Humans, Nervous System Diseases, Neuroprotective Agents, Neurosciences, Translational Medical Research