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A rise in cytosolic Ca 2+ concentration is used as a universal signalling mechanism to control biological processes as diverse as exocytosis, contraction, cell growth and cell death. Ca 2+ signals are often presented to cells in the form of Ca 2+ oscillations, with signalling information encoded in both amplitude and frequency of the Ca 2+ spikes. Recent studies have revealed that the sub-cellular spatial profile of the Ca 2+ oscillation is also important in activating cellular responses, thereby suggesting a new mechanism for extracting information from he ubiquitous Ca 2+ oscillation. © 2010 Elsevier Ltd.

Original publication




Journal article


Trends in Biochemical Sciences

Publication Date





78 - 87