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We have examined the voltage-dependent properties of single L-type Ca channels in cell-attached patches on mouse pancreatic β-cells using 10 mM Ba2+ as the charge carrier, a Ba-concentration that produces minimal voltage shift. The voltage dependence of channel activation was consistent with the participation of L-type Ca channels in both the plateau potential and the action potential phases of β-cell electrical activity. In addition, single channel currents were observed at the resting potential suggesting Ca2+ influx through these L-type Ca channels contributes to background Ca2+ entry into the β-cell.


Conference paper

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61 - 63