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Haemolysis of human blood has been examined in vitro as a function of pH in the range 7.2-8.0. The hydrogen ion concentration of freshly donated blood from 11 donors was manipulated in 42 experiments, entirely by altering the carbon dioxide fraction of air with which the blood was equilibrated using a membrane lung. In contrast to the known alkalaemic haemolysis which occurs in canine blood, we observed no correlation between plasma haemoglobin concentrations and blood pH. We conclude that alkalaemic haemolysis is unlikely to complicate the clinical application of extracorporeal carbon dioxide removal in the management of acute respiratory failure.

Type

Journal article

Journal

J Biomed Eng

Publication Date

09/1989

Volume

11

Pages

369 - 374

Keywords

Acid-Base Equilibrium, Adult, Artificial Organs, Carbon Dioxide, Female, Hematocrit, Hemolysis, Humans, Lung, Male, Membranes, Artificial, Middle Aged, Potassium, Sodium