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Mutations in human doublecortin (DCX) and knockdown of Dcx in rodents cause radial migration defects in the embryonic cerebral cortex. However, the brain phenotype of Dcx knockout mice is largely normal suggesting that Dcx is not necessary for most migration events. Adult subventricular zone (SVZ) cells migrate tangentially in the rostral migratory stream to the olfactory bulbs. Dcx is expressed in the SVZ but it is unknown if it is necessary for migration. We show that Dcx RNAi reduced SVZ cell migration in vitro, both cell autonomously and non-cell autonomously. Overexpression of Dcx rescued migration after knockdown, but did not increase migration by itself. Thus, Dcx is necessary not only for embryonic radial migration but also migration of adult SVZ cells.

Original publication

DOI

10.1016/j.mcn.2006.06.014

Type

Journal article

Journal

Mol Cell Neurosci

Publication Date

10/2006

Volume

33

Pages

126 - 135

Keywords

3' Untranslated Regions, Age Factors, Animals, Brain, Cell Movement, Cerebral Cortex, HeLa Cells, Humans, Lateral Ventricles, Male, Mice, Mice, Knockout, Microscopy, Video, Microtubule-Associated Proteins, Neuropeptides, Olfactory Bulb, Phenotype, RNA Interference, RNA, Messenger, Spheroids, Cellular