Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Ba currents flowing through single Ca-channels were recorded from cell-attached patches on rat pancreatic beta-cells. Two types of voltage-activated Ca-channels were found. The first (T-type) had a single channel conductance of 8 pS in 100 mM Ba, was activated at a low threshold (around -50mV) and inactivated by holding potentials positive to -40 mV. These properties are similar to those described for T-type channels in other preparations. The second type of Ca-channel (L-type) had a single channel conductance of 20pS in 100 mM Ba, was activated at a higher threshold (greater than -30mV), showed little inactivation during a 250 ms pulse and could be activated from a holding potential of -40mV. The dihydropyridine agonist BAY K 8644 selectively prolonged L-type Ca-channel openings. These properties are characteristic of L-type Ca-channels.


Journal article


Pflugers Arch

Publication Date





504 - 506


3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester, Animals, Barium, Calcium Channels, Culture Techniques, Islets of Langerhans, Rats