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This review of ventilatory acclimatization to altitude/hypoxia (VAH) emphasizes the widely differing timescales that VAH is considered to encompass. The review concludes: (1) that early (24-48h) VAH is unlikely to arise as a reaction to the respiratory alkalosis that is normally associated with exposure to hypoxia; (2) that changes in peripheral chemoreflex function may be sufficiently rapid to explain early VAH; (3) that alterations in gene expression induced by hypoxia through the hypoxia-inducible factor (HIF) signalling pathway may underlie a major component of VAH; and (4) that compensatory adjustments to acid-base balance in response to the initial respiratory alkalosis may have more significance for the slower changes observed later in VAH.

Original publication

DOI

10.1016/j.resp.2007.03.008

Type

Journal article

Journal

Respir Physiol Neurobiol

Publication Date

30/09/2007

Volume

158

Pages

237 - 242

Keywords

Acclimatization, Acid-Base Equilibrium, Altitude, Animals, Carbon Dioxide, Chemoreceptor Cells, Humans, Hypoxia, Oxygen, Peripheral Nervous System, Pulmonary Ventilation, Reflex, Time Factors