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the present invention relates to peptides, in particular cell-penetrating peptides, having a first hydrophobic domain positioned at the C-terminus of the peptide and a second hydrophobic domain positioned at the N-terminus of the peptide, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.



Publication Date



Oxford University Innovation Limited, University of Oxford, Buxton Court 3 West Way, Oxford, OX2 OJB, United Kingdom, United Kindgdom Research and Innovation, Polaris House North Star Avenue, Swindon, Wiltshire, SN2 1FL, United Kingdom