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© 2009 Elsevier Ltd All rights reserved. While epilepsy constitutes a heterogeneous array of disorders, the conventional view is that there is a common underlying failure in the ability of synaptic inhibition to balance excitation. This hypothesis is supported by the fact that eroding GABA receptor-mediated inhibition leads to massive synchronous discharges in neuronal circuits. However, GABAergic inhibition is known to play a fundamental role in the orchestration of physiological brain rhythms and could also play a proactive role in the generation and synchronization of seizure activity. A more detailed understanding of how the multiple facets of GABAergic inhibition contribute differentially to sculpting both physiological and pathological network activity may pave the way for more selective therapeutic strategies.

Original publication





Book title

Encyclopedia of Basic Epilepsy Research

Publication Date



314 - 319