Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Li P-K., Xiao Z., Hu Z., Pandit B., Sun Y., Sackett DL., Werbovetz K., Lewis A., Johnsamuel J.
A series of compounds originally derived from the vascular endothelial growth factor receptor tyrosine kinase inhibitor, SU5416, was synthesized and evaluated. The most potent compound in this series, compound 7, structurally resembles the potent anti-microtubule agent Combretastatin A-4, inhibited tubulin polymerization, and showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in low to subnanomolar range.