Inhibitors of NF-kappaB derived from thalidomide.
de-Blanco EJC., Pandit B., Hu Z., Shi J., Lewis A., Li P-K.
A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-kappaB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF-kappaB activation is through inhibition of its translocation from the cytoplasm to the nucleus.