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INTRODUCTION: In asthma, lung function measures are often discordant with clinical features such as disease activity or control. METHODS: We investigated a novel technique that provides a measure (σCL) of unevenness (inhomogeneity) in lung inflation/deflation. In particular, we compared σCL with FEV1% predicted (FEV1%pred) as measures of disease activity in the asthmatic lung. RESULTS: σCL correlated modestly with FEV1%pred. However, σCL is not simply a proxy for FEV1%pred as the effects of salbutamol on the two parameters were unrelated. Importantly, σCL reflected disease control better than FEV1. DISCUSSION: We conclude that σCL shows promise as an objective measure of disease activity in asthma.

Original publication




Journal article


BMJ Open Respir Res

Publication Date





asthma, Adult, Aged, Albuterol, Asthma, Bronchodilator Agents, Case-Control Studies, Female, Forced Expiratory Volume, Humans, Lung, Male, Middle Aged, Pulmonary Gas Exchange, Severity of Illness Index, Spirometry