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Elevation of cytosolic Ca(2+) levels through the activation of store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels is involved in mediating a disparate array of cellular responses. These include secretion, metabolism and gene expression, as well as cell growth and proliferation. Moreover, emerging evidence points to the involvement of aberrant CRAC channel activity in human diseases, such as certain types of immunodeficiency and autoimmunity disorders, allergy, and inflammatory bowel disease. This article summarizes recent advances in understanding the gating and function of CRAC channels, their links to human disease and key issues for the development of channel blockers.

Original publication




Journal article


Nat Rev Drug Discov

Publication Date





399 - 410


Animals, Calcium, Calcium Channel Blockers, Calcium Channels, Cell Proliferation, Drug Delivery Systems, Drug Design, Gene Expression Regulation, Humans, Immune System Diseases, Inflammatory Bowel Diseases