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We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development.

Original publication




Journal article


Mech Dev

Publication Date





289 - 292


Amino Acid Sequence, Animals, Animals, Genetically Modified, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cloning, Molecular, Gene Expression Regulation, Developmental, Genes, Helminth, Green Fluorescent Proteins, Luminescent Proteins, Mice, Molecular Sequence Data, Recombinant Fusion Proteins, Sequence Homology, Amino Acid