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Bioresponsive contrast agents can provide smart signaling in MRI. In wrapping pore functionalised Gd-DOTA mesoporous silica nanoparticles with pH-responsive poly(acrylic acid), exchange between pore and bulk water can be reversibly switched by local pH. The generated high contrast then exhibits a large amplitude switch in a manner relevant to environmentally responsive imaging.

Original publication

DOI

10.1039/c9cc03312b

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

18/07/2019

Volume

55

Pages

8540 - 8543