Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Event video for the inaugural John Scott Haldane Lecture 2019, delivered by Professor Sir Peter J Ratcliffe FRS on Thursday 21 November 2019 in the Sherrington Large Lecture Theatre.

In 1911, work by Haldane, Fitzgerald and colleagues revealed the extraordinary sensitivity of blood haemoglobin levels to reduced atmospheric oxygen levels, a finding that introduced the physiological concept of an oxygen sensor. This lecture outlines advances in the molecular understanding of oxygen sensing mechanisms, including the remarkable finding that all eukaryotic kingdoms use enzymatic protein oxidations coupled to proteostasis to signal oxygen levels in their cells. The physiological implications of these advances are discussed, together with the opportunities and challenges raised in the therapeutic modulation of human oxygen sensing systems.

Professor Sir Peter J Ratcliffe FRS is Director of the Target Discovery Institute, and a Member of the Ludwig Institute for Cancer Research. He is a Fellow of the Royal Society and the Academy of Medical Sciences and is an honorary member of the American Academy of Arts and Sciences. In the 2014 New Year’s Honours List, he was knighted for services to clinical medicine.

In October 2019, Professor Ratcliffe was awarded the Nobel Prize in Physiology or Medicine, alongside William Kaelin Jr at Harvard University and Gregg Semenza at Johns Hopkins University. Click here for more information.

 

The video of the J.S. Haldane Lecture is also available to watch on The University of Oxford Podcasts website.

Similar stories

Thomas Willis (1621 - 1675) 400th Birthday - Alastair Buchan in conversation with Zoltán Molnár

General Research

Professor Zoltán Molnár talks to Pro-Vice-Chancellor Professor Alastair Buchan to learn more about Thomas Willis's residence and base for scientific discoveries, Beam Hall.

Thomas Willis (1621 - 1675) 400th Birthday - Erica Charters in conversation with Zoltán Molnár

General Research

Professor Zoltán Molnár talks to Dr Erica Charters for a History of Medicine perspective on Oxford physician and Father of Neurology Thomas Willis.

Thomas Willis 400th anniversary trailer

General Research

On 27 January 2021 we celebrate the 400th anniversary of the birth of the greatest neuroanatomist of all time, Thomas Willis. DPAG's Professor Zoltán Molnár has interviewed 8 experts - watch a video preview of what's to come from Monday onwards! With thanks to St John's College.

New Nanoscience Institute to advance physiology research in Oxford

Head of Department's News

A new institute for nanoscience research is to open in Oxford thanks to a $10 million gift from The Kavli Foundation, the ground floor of which will be home to cutting-edge new research avenues across the six themes of DPAG.

Lukas Krone to represent Oxford at the Global Young Scientists Summit

Awards and Honours EDI News Head of Department's News Students Vyazovskiy Group News

Congratulations are in order for Dr Lukas Krone who is one of just five University of Oxford researchers selected to attend the Global Young Scientists Summit 2021.

Pawel Swietach becomes Professor Pawel Swietach

Awards and Honours Head of Department's News

Congratulations are in order to Pawel Swietach on his conferral of the title of full Professor. Research in the Swietach Lab is driven by an interest in how biological processes are affected by chemical acidity.