Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Event video for the inaugural John Scott Haldane Lecture 2019, delivered by Professor Sir Peter J Ratcliffe FRS on Thursday 21 November 2019 in the Sherrington Large Lecture Theatre.

In 1911, work by Haldane, Fitzgerald and colleagues revealed the extraordinary sensitivity of blood haemoglobin levels to reduced atmospheric oxygen levels, a finding that introduced the physiological concept of an oxygen sensor. This lecture outlines advances in the molecular understanding of oxygen sensing mechanisms, including the remarkable finding that all eukaryotic kingdoms use enzymatic protein oxidations coupled to proteostasis to signal oxygen levels in their cells. The physiological implications of these advances are discussed, together with the opportunities and challenges raised in the therapeutic modulation of human oxygen sensing systems.

Professor Sir Peter J Ratcliffe FRS is Director of the Target Discovery Institute, and a Member of the Ludwig Institute for Cancer Research. He is a Fellow of the Royal Society and the Academy of Medical Sciences and is an honorary member of the American Academy of Arts and Sciences. In the 2014 New Year’s Honours List, he was knighted for services to clinical medicine.

In October 2019, Professor Ratcliffe was awarded the Nobel Prize in Physiology or Medicine, alongside William Kaelin Jr at Harvard University and Gregg Semenza at Johns Hopkins University. Click here for more information.

 

The video of the J.S. Haldane Lecture is also available to watch on The University of Oxford Podcasts website.

Similar stories

Professor Dame Sue Black to deliver 2022 Christmas Lectures

In the 2022 Christmas Lectures from the Royal Institution, DPAG's Visiting Professor of Forensic Anatomy Dame Sue Black will share secrets of forensic science.

Professor Dame Sue Black joins DPAG as Visiting Professor of Forensic Anatomy

The Department welcomes Professor Dame Sue Black DBE OBE FRSE FBA FRAI FRSB ChFA, Baroness Black of Strome and one of the world’s leading forensic scientists, as our Visiting Professor of Forensic Anatomy.

DPAG has two new Professors

Congratulations are in order to Ana Domingos and Nicola Smart who have been awarded the title of Professor in the recent Recognition of Distinction round.

IDRM officially opens in Oxford

A celebration for the opening of the Institute of Developmental & Regenerative Medicine (IDRM) led by Paul Riley took place on Tuesday 12 July 2022, attended by many DPAG members who have recently relocated to this fantastic new Institute.

Annual Report 2021 - 2022

The Department's Annual Report for the academic year 2021-22 has been released. The brochure showcases a selection of the year's highlights, including another top world ranking for Anatomy and Physiology and a strong contribution to the University of Oxford's success to Unit of Assessment 5 in the National Research Excellence framework (2021).