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Our team

Latest publications

Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading

Preprint

Cramb KML. et al, (2026)

CHCHD2 links mitochondrial dysfunction and α-synuclein misfolding in Parkinson's disease.

Journal article

Narendra D. and Ryan BJ., (2026), Trends Neurosci

M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress.

Journal article

Elbæk CR. et al, (2026), Cell Death Differ

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.

Journal article

Loreto A. et al, (2025), Neurobiol Dis, 213

Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling.

Journal article

Mikulski P. et al, (2025), Nat Struct Mol Biol, 32, 1255 - 1267

Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons.

Journal article

Schmidt SI. et al, (2025), NPJ Parkinsons Dis, 11

Recent developments in gene therapy for Parkinson's disease.

Journal article

Szunyogh S. et al, (2025), Mol Ther, 33, 2052 - 2064

TFEB and TFE3 have cell-type specific expression in the brain and divergent roles in neurons

Preprint

McGuinness W. et al, (2025)

USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms

Preprint

Williamson MG. et al, (2025)

Tau depletion in human neurons mitigates Aβ-driven toxicity.

Journal article

Ng B. et al, (2024), Mol Psychiatry, 29, 2009 - 2020

A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy.

Journal article

Nebuloni F. et al, (2024), Lab Chip, 24, 3252 - 3264

CRISPRi: a way to integrate iPSC-derived neuronal models.

Journal article

Franks SNJ. et al, (2024), Biochem Soc Trans, 52, 539 - 551

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation.

Journal article

Do QB. et al, (2024), NPJ Parkinsons Dis, 10

Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease.

Journal article

Kilfeather P. et al, (2024), Cell Rep, 43

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.

Journal article

Brimblecombe KR. et al, (2024), Eur J Neurosci, 59, 1242 - 1259

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.

Journal article

Hasan S. et al, (2023), Mol Neurodegener, 18

Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications

Preprint

Mikulski P. et al, (2023)

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.

Journal article

Hasan S. et al, (2023), Mol Neurodegener, 18

A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy

Preprint

Nebuloni F. et al, (2023)

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.

Journal article

Vahsen BF. et al, (2023), Nat Commun, 14