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The cephalic phase of insulin secretion (CPIS) plays a crucial role in glucose homeostasis. However, the neural basis of CPIS and its overall relevance to metabolic health are poorly understood. Here, we preview the findings of Wiedemann et al. (2022) that address the role of IL-1β in the integration of neuro-mediated insulin release following cephalic stimulation and CPIS dysregulation in obesity.

Original publication

DOI

10.1016/j.cmet.2022.06.005

Type

Journal article

Journal

Cell Metab

Publication Date

05/07/2022

Volume

34

Pages

940 - 942

Keywords

Humans, Insulin, Insulin Secretion, Obesity