Photo by Stuart Bebb
Contact information
Research groups
Colleges
Collaborators
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Stephanie Cragg
Professor of Neuroscience
Lauren Burgeno
BS PhD
National Science Foundation Postdoctoral Research Fellow in Biology
- Dan Norman Early Career Research Fellow in Addiction, Balliol College
I earned my PhD in Pharmacology in 2017 from the University of Washington where I worked under the mentorship of Dr. Paul Phillips, investigating the roles that drug-cue elicited phasic dopamine release plays in controlling drug-taking vs. drug-seeking behaviors.
As a postdoctoral researcher at Oxford, I work in the laboratories of Prof. Stephanie Cragg (DPAG) and Dr. Mark Walton (Experimental Psychology). My main interest lies in understanding the mechanisms by which striatal acetylcholine gates cue-elicited dopamine release in real-time during behavior. Ultimately I hope to determine how this interaction contributes to addiction related behavior.
My studies utilize a combination of approaches, including in vivo fast-scan cyclic voltammetry, optogenetics and photometry, to measure and manipulate dopaminergic and cholinergic activity during reward guided behavioral paradigms.
Key publications
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Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use.
Journal article
Willuhn I. et al, (2012), Proc Natl Acad Sci U S A, 109, 20703 - 20708
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Excessive cocaine use results from decreased phasic dopamine signaling in the striatum.
Journal article
Willuhn I. et al, (2014), Nat Neurosci, 17, 704 - 709
Recent publications
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Lights, fiber, action! A primer on in vivo fiber photometry.
Journal article
Simpson EH. et al, (2024), Neuron, 112, 718 - 739
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Time-dependent assessment of stimulus-evoked regional dopamine release.
Journal article
Lippert RN. et al, (2019), Nat Commun, 10
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Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
Journal article
Schattauer SS. et al, (2017), Nat Commun, 8
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Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release.
Journal article
Pes R. et al, (2017), Neuropharmacology, 114, 77 - 87
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Genetic Isolation of Hypothalamic Neurons that Regulate Context-Specific Male Social Behavior.
Journal article
Soden ME. et al, (2016), Cell Rep, 16, 304 - 313
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Stress effects on the neural substrates of motivated behavior.
Journal article
Hollon NG. et al, (2015), Nat Neurosci, 18, 1405 - 1412
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Fast Scan Cyclic Voltammetry in Behaving Animals
Chapter
ARNOLD MA. et al, (2015), Basic Electrophysiological Methods, 108 - 133