Camille Goldman

I completed my PhD at the Icahn School of Medicine at Mount Sinai in New York (USA) in 2025, under the supervision of Dr. Joel Blanchard and Dr. Alison Goate. My thesis work focused on developing iPSC-derived models of human brain tissue to study the molecular mechanisms promoting Lewy body diseases. I particularly focused on the contribution of APOE4 and cholesterol dysregulation in astrocytes on neuronal pathology. I am currently a postdoctoral researcher in Dr. Hugo Fernandes' laboratory. My research is focused on mixed pathologies in Alzheimer's disease (AD). AD is characterized by the toxic aggregation of the proteins amyloid-b and tau. However, there is mounting evidence that the majority of AD patients also have TDP-43 and a-synuclein co-pathologies. However, do not currently understand how the different pathological processes interact to contribute to neurodegeneration and cognitive decline. I am using iPSC neurons and microglia to identify how protein aggregates isolated from "pure-pathology" and "mixed-pathology" AD donor brains uniquely alter neuroinflammatory pathways to contribute to neurodegeneration.