PhD MRes BSc
Postdoctoral Research Associate
I have had a long-standing interest in cardiovascular biology since undertaking my BSc in Biomedical Sciences, in which I graduated in 2013 from the University of Manchester. I consequently obtained a distinction in MRes Cardiovascular Health and Disease in 2015 from the University of Manchester. My research project, performed under the supervision of Prof Mark Boyett and Dr Alicia D'Souza, investigated the circadian rhythms in bradyarrhythmia. I also assessed ECGs to identify changes in heart rate following exercise training.
In 2016, I started my PhD in Prof David Grieve's lab at Queen's University Belfast (secondary supervisor Prof Tim Curtis). I investigated the role of endothelial NADPH oxidases (specifically Nox2 and Nox4) on diabetic cardiac remodeling. I developed a wide range of skills including in vivo (echocardiography, blood pressure, osmotic mini-pump insertion), ex vivo (histology, IHC), in vitro (culture of endothelial/fibroblast/cardiomyocyte cells, migration/proliferation/ROS assays, flow cytometry) and molecular biology (PCR, Western blots). In 2021, I joined Newcastle University, where I spent a year developing nuclei isolations for snRNAseq to identify key regulators of aortic arch artery morphogenesis.
I joined Prof Pawel Swietach's lab in 2022. My current project is investigating the role of sodium bicarbonate transporters in regulation of pH and the development of cardiac hypertrophy. This is an exciting three year project using various in vivo and in vitro mechanisms to elucidate the role of pH in cardiac hypertrophy.