Armin Lak
Associate Professor of Neuroscience
- Wellcome Trust Henry Dale Fellow
- St John's College Fellow
My group aims to gain a quantitative circuit-level understanding of neuronal mechanisms that subserve learning and decision making. We employ a multi-disciplinary approach including high-count electrophysiology, cell type-specific multi-phton imaging, optogenetic manipulations, highly-controlled behavioural tasks in mice, and computational modelling. Our research is supported by funding from ERC and Wellcome Trust
I completed my PhD in neuroscience at Cambridge University with Wolfram Schultz, investigating the roles of midbrain dopamine neurons in economic decision making. As a Sir Henry Wellcome Postdoctoral Fellow, I worked with Matteo Carandini, Kenneth Harris and Adam Kepecs at UCL (London) and CSHL (NY). I combined neuronal circuit tools with novel behavioural and computational methods that I developed to investigate the roles that frontal cortex and dopamine neurons play in perceptual and economic decisions.
Colleges
Research groups
Key publications
Distinct representations of economic variables across regions and projections of the frontal cortex.
Journal article
Majumdar A. et al, (2025), Neuron, 113, 4232 - 4244.e8
Dopamine encodes deep network teaching signals for individual learning trajectories.
Journal article
Liebana S. et al, (2025), Cell, 188, 3789 - 3805.e33
Temporal regularities shape perceptual decisions and striatal dopamine signals.
Journal article
Fritsche M. et al, (2024), Nat Commun, 15
Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value.
Journal article
Lak A. et al, (2020), Neuron, 105, 700 - 711.e6
Orbitofrontal cortex is required for optimal waiting based on decision confidence.
Journal article
Lak A. et al, (2014), Neuron, 84, 190 - 201
Dopamine prediction error responses integrate subjective value from different reward dimensions.
Journal article
Lak A. et al, (2014), Proc Natl Acad Sci U S A, 111, 2343 - 2348
Recent publications
Distinct representations of economic variables across regions and projections of the frontal cortex.
Journal article
Majumdar A. et al, (2025), Neuron, 113, 4232 - 4244.e8
Dopamine encodes deep network teaching signals for individual learning trajectories.
Journal article
Liebana S. et al, (2025), Cell, 188, 3789 - 3805.e33
ierarchical adaptive optics strategy for three-photon imaging during behavior
Preprint
Atilgan H. et al, (2025)
n orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour.
Journal article
Messore F. et al, (2025), Transl Psychiatry, 15
n axonal brake on striatal dopamine output by cholinergic interneurons.
Journal article
Zhang Y-F. et al, (2025), Nat Neurosci, 28, 783 - 794

