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Publications

The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload.

Mohammad G. et al, (2021), Kidney Int

Fetal liver hepcidin secures iron stores in utero.

Kämmerer L. et al, (2020), Blood, 136, 1549 - 1557

Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.

Bessman NJ. et al, (2020), Science, 368, 186 - 189

Ferroportin-mediated iron export from vascular endothelial cells in retina and brain.

Baumann BH. et al, (2019), Exp Eye Res, 187

Liver-Specific, but Not Retina-Specific, Hepcidin Knockout Causes Retinal Iron Accumulation and Degeneration.

Baumann BH. et al, (2019), Am J Pathol, 189, 1814 - 1830

Iron Deficiency as a Therapeutic Target in Cardiovascular Disease.

Lakhal-Littleton S., (2019), Pharmaceuticals (Basel), 12

IMPACTS OF MATERNAL IRON DEFICIENCY ON THE MOUSE PLACENTAL-HEART AXIS

Kalisch-Smith J. et al, (2019), PLACENTA, 83, E47 - E48

Ferroportin promotes iron import through the retinal vascular endothelium

Shu W. et al, (2019), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60

Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.

Lakhal-Littleton S. et al, (2019), Proc Natl Acad Sci U S A, 116, 13122 - 13130

IRON DEFICIENCY IN PULMONARY ARTERIAL SMOOTH MUSCLE CELLS INDUCES PULMONARY ARTERIAL HYPERTENSION THROUGH ENDOTHELIN-1

Lakhal-Littleton S. et al, (2019), HEART, 105, A142 - A143

Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.

Chung YJ. et al, (2019), JCI Insight, 4

Mechanisms of cardiac iron homeostasis and their importance to heart function.

Lakhal-Littleton S., (2019), Free Radic Biol Med, 133, 234 - 237

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.

Schwartz AJ. et al, (2019), J Clin Invest, 129, 336 - 348

Cardiomyocyte hepcidin: From intracellular iron homeostasis to physiological function.

Lakhal-Littleton S., (2019), 110, 189 - 200

Hepatic hepcidin/intestinal HIF-2a axis maintains iron absorption during iron deficiency and overload

LAKHAL-LITTLETON S., (2018), Journal of Clinical Investigation

The interplay between iron and oxygen homeostasis with a particular focus on the heart.

Lakhal-Littleton S. and Robbins PA., (2017), J Appl Physiol (1985), 123, 967 - 973

LOSS OF LOCAL HEPCIDIN DECREASES TUMORIGENESIS IN COLORECTAL CANCER

Schwartz A. et al, (2017), AMERICAN JOURNAL OF HEMATOLOGY, 92, E211 - E211

Environmental influences on mouse embryonic heart development

Sparrow D. et al, (2017), MECHANISMS OF DEVELOPMENT, 145, S157 - S158

THE CARDIAC HEPCIDIN/FERROPORTIN AXIS IS ESSNTIAL FOR CARDIAC IRON HOMEOSTASIS AND FUNCTION

Lakhal-Littleton S. et al, (2017), HEART, 103, A137 - A137

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.

Lakhal-Littleton S. et al, (2016), Elife, 5

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