Synthesis of Aryl-fused Bicyclo[3.1.1]heptanes (BCHeps) and Validation as Naphthyl Bioisosteres
Kerckhoffs A. et al, (2024)
A missense mutation in zinc finger homeobox‐3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice
Nolan PM. et al, (2023), The FASEB Journal, 37
Long-Acting PTH/PTHrP Hybrid Analogue Rectifies Hypocalcemia in a Mouse Model for Autosomal Dominant Hypocalcemia Type-1 (ADH1)
Hannan F. et al, (2023), JOURNAL OF BONE AND MINERAL RESEARCH, 38, 31 - 31
Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.
Chatzopoulou M. et al, (2020), ACS Med Chem Lett, 11, 2421 - 2427
2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.
Babbs A. et al, (2020), J Med Chem, 63, 7880 - 7891
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
Wilkinson IVL. et al, (2020), Angew Chem Int Ed Engl, 59, 2420 - 2428
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.
Babbs A. et al, (2020), Tetrahedron, 76
The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy.
Guiraud S. et al, (2019), Hum Mol Genet, 28, 2189 - 2200
Embryonic myosin is a regeneration marker to monitor utrophin-based therapies for DMD.
Guiraud S. et al, (2019), Hum Mol Genet, 28, 307 - 319
Micro-utrophin Improves Cardiac and Skeletal Muscle Function of Severely Affected D2/mdx Mice.
Kennedy TL. et al, (2018), Mol Ther Methods Clin Dev, 11, 92 - 105
A genetic modifier suggests that endurance exercise exacerbates Huntington's disease
Corrochano S. et al, (2018), Human Molecular Genetics, 27, 1723 - 1731
Small molecule utrophin modulators for the therapy of Duchenne muscular dystrophy (DMD)
Russell A. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256
Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety
Moir L. et al, (2017), Molecular Metabolism, 6, 1419 - 1428
Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle.
Kennedy TL. et al, (2017), Skelet Muscle, 7
Discovery of small molecule utrophin modulators for the therapy of Duchenne muscular dystrophy
Wynne G. et al, (2017), NEUROMUSCULAR DISORDERS, 27, S189 - S189
Comprehensive Energy Balance Measurements in Mice.
Moir L. et al, (2016), Curr Protoc Mouse Biol, 6, 211 - 222
Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.
Goldsworthy M. et al, (2013), PLoS One, 8

