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Publications

Store-Operated Ca2+ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets.

Bakowski D. et al, (2020), Annu Rev Pharmacol Toxicol

Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression.

Yeh Y-C. et al, (2019), Hum Mol Genet

Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters.

Lin Y-P. et al, (2019), Nat Commun, 10

Calcium signalling in health and disease.

Parekh AB., (2019), Semin Cell Dev Biol

The whole-cell Ca2+ release-activated Ca2+ current, ICRAC , is regulated by the mitochondrial Ca2+ uniporter channel and is independent of extracellular and cytosolic Na.

Samanta K. et al, (2018), J Physiol

The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca2+ Channels and Mast Cell Migration through PAR4 Receptors.

Lin Y-P. et al, (2018), Mol Cell, 70, 228 - 241.e5

Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria.

Samanta K. et al, (2018), Nat Commun, 9

New insights into Ca2+ channel function in health and disease.

Fleig A. and Parekh AB., (2017), J Physiol, 595, 2997 - 2998

Spatial Ca2+ profiling: decrypting the universal cytosolic Ca2+ oscillation.

Samanta K. and Parekh AB., (2017), J Physiol, 595, 3053 - 3062

Regulation of CRAC channels by Ca2+-dependent inactivation.

Parekh AB., (2017), Cell Calcium, 63, 20 - 23

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals.

Kar P. et al, (2016), Mol Cell, 64, 746 - 759

Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma.

Samanta K. and Parekh AB., (2016), Philos Trans R Soc Lond B Biol Sci, 371

Ca2+ Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors.

Alswied A. and Parekh AB., (2015), J Biol Chem, 290, 29555 - 29566

Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression.

Samanta K. et al, (2015), Cell Rep, 12, 203 - 216

Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms.

Kar P. and Parekh AB., (2015), Mol Cell, 58, 232 - 243

Distinct structural domains of caveolin-1 independently regulate Ca2+ release-activated Ca2+ channels and Ca2+ microdomain-dependent gene expression.

Yeh Y-C. and Parekh AB., (2015), Mol Cell Biol, 35, 1341 - 1349

Caveolin-1 alters the pattern of cytoplasmic Ca2+ oscillations and Ca2+-dependent gene expression by enhancing leukotriene receptor desensitization.

Yeh Y-C. et al, (2014), J Biol Chem, 289, 17843 - 17853

Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.

Kar P. et al, (2014), Curr Biol, 24, 1361 - 1368

An introduction to the Bioscience Birthday Symposium held in honour of Ole Petersen CBE, FRS.

Parekh AB., (2014), J Physiol, 592, 259 - 260

Key role for store-operated Ca2+ channels in activating gene expression in human airway bronchial epithelial cells.

Samanta K. et al, (2014), PLoS One, 9

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