Store-Operated Ca2+ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets.
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Single-nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression.
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The whole-cell Ca2+ release-activated Ca2+ current, ICRAC , is regulated by the mitochondrial Ca2+ uniporter channel and is independent of extracellular and cytosolic Na.
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Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters.
Lin Y-P. et al, (2019), Nat Commun, 10
The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca2+ Channels and Mast Cell Migration through PAR4 Receptors.
Lin Y-P. et al, (2018), Mol Cell, 70, 228 - 241.e5
Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria.
Samanta K. et al, (2018), Nat Commun, 9
New insights into Ca2+ channel function in health and disease.
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Spatial Ca2+ profiling: decrypting the universal cytosolic Ca2+ oscillation.
Samanta K. and Parekh AB., (2017), J Physiol, 595, 3053 - 3062
Regulation of CRAC channels by Ca2+-dependent inactivation.
Parekh AB., (2017), Cell Calcium, 63, 20 - 23
Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals.
Kar P. et al, (2016), Mol Cell, 64, 746 - 759
Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma.
Samanta K. and Parekh AB., (2016), Philos Trans R Soc Lond B Biol Sci, 371
Ca2+ Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors.
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Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression.
Samanta K. et al, (2015), Cell Rep, 12, 203 - 216
Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms.
Kar P. and Parekh AB., (2015), Mol Cell, 58, 232 - 243
Distinct structural domains of caveolin-1 independently regulate Ca2+ release-activated Ca2+ channels and Ca2+ microdomain-dependent gene expression.
Yeh Y-C. and Parekh AB., (2015), Mol Cell Biol, 35, 1341 - 1349
Caveolin-1 alters the pattern of cytoplasmic Ca2+ oscillations and Ca2+-dependent gene expression by enhancing leukotriene receptor desensitization.
Yeh Y-C. et al, (2014), J Biol Chem, 289, 17843 - 17853
Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.
Kar P. et al, (2014), Curr Biol, 24, 1361 - 1368
An introduction to the Bioscience Birthday Symposium held in honour of Ole Petersen CBE, FRS.
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