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Contact information


carolyn.carr@dpag.ox.ac.uk


01865 282247

Research groups

Websites

Carolyn Carr

Associate Professor of Biomedical Science

I am afraid I am not taking on any new students as I am approaching retirement.


I joined the department in 2003 and my research interests include cardiac physiology and metabolism and the use of endogenous cardiac stem cells to prevent heart failure. My research has shown that both endogenous cardiac progenitor cells and induced pluripotent stem cells significantly improve function of the heart after myocardial infarction. However, with both cell types, the improvement in function was not large and so we are now exploring tissue engineering solutions for cell delivery. We characterised changes in cell metabolism as the cells differentiate into beating cardiomyocytes and modified the culture conditions to make the cells switch to a more mature metabolic phenotype. We also made the cells insulin resistant to generate an in vitro model of the cells in the diabetic heart.

I started life as a chemist, doing my undergraduate degree and my DPhil in Chemistry at the University of Oxford. I worked with MR spectroscopy and mass spectrometry both within the Chemistry Department here in Oxford and also in industry for Kodak Ltd and Synaptica Ltd. During my DPhil, I used MRS to study the conformation of small molecules in solution and as a post-doc I moved on to study the conformation of larger molecules such as peptides and proteins. Since joining the CMRG, I have been using MR imaging to measure heart function. 

I had a career break to stay at home with my children and returned to science with a Daphne Jackson Fellowship which offers two year part-time research for returners to SET. Fellows carry out a supervised research project and a retraining programme at a UK University or research laboratory. This is an excellent scheme that I recommend to anyone on a career break and looking to return to science.


Outreach


I am on the Board of Trustees for the Oxford International Biomedical Centre which organises talks by Scientists in Schools. I have given talks about my work to BHF fund-raising groups and to local schools and was interviewed for the local press.