Kieran Clarke
PhD
Emeritus Professor of Physiological Biochemistry
Since 1991, Professor Kieran Clarke has worked at the University of Oxford on the effects of diet on energy metabolism in human heart, brain and skeletal muscle. Specifically, her interest in physical and cognitive function has led to the development of a fourth food group, a ketone ester called ΔG®, that improves endurance exercise in athletes and could be used for the management of common metabolic diseases, such as type 2 diabetes.
Before Oxford, Professor Clarke worked as a postdoctoral fellow at Harvard University Medical School and as a research scientist at the NRC in Ottawa, Canada.
Key publications
Prior ingestion of exogenous ketone monoester attenuates the glycaemic response to an oral glucose tolerance test in healthy young individuals.
Journal article
Myette-Côté É. et al, (2018), J Physiol, 596, 1385 - 1395
Ketone bodies mimic the life span extending properties of caloric restriction.
Journal article
Veech RL. et al, (2017), IUBMB Life, 69, 305 - 314
On the Metabolism of Exogenous Ketones in Humans.
Journal article
Stubbs BJ. et al, (2017), Front Physiol, 8
Novel ketone diet enhances physical and cognitive performance.
Journal article
Murray AJ. et al, (2016), FASEB J, 30, 4021 - 4032
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.
Journal article
Cox PJ. et al, (2016), Cell Metab, 24, 256 - 268
Recent publications
Ketosis Elevates Antioxidants and Markers of Energy Metabolism: A Proton Magnetic Resonance Spectroscopy Study.
Journal article
van Nieuwenhuizen H. et al, (2025), Biol Psychiatry Cogn Neurosci Neuroimaging, 10, 1186 - 1196